After losing in overtime to the Chiefs in Super Bowl 58, the 49ers open the season against the Jets on Monday Night Football. It’s the final game of Week 1 and could be seen as a preview of Super Bowl 59, with Aaron Rodgers returning from a torn Achilles and both teams having strong rosters. San Francisco is a 4.5-point home favorite in the latest Week 1 NFL odds, but they were 9-11 against the spread last season.
Meanwhile, the Lions finished as runners-up in the NFC and will open the season against the Los Angeles Rams on Sunday Night Football in a rematch of last season’s NFC Wild Card game. Detroit is favored by 3.5 points on the NFL spread and NFL betting lines. Let’s take a look at who you should bet on in these games when making your Week 1 NFL score predictions, as well as which NFL lines the oddsmakers got totally wrong in Week 1. Before making any Week 1 NFL picks, you should check out the NFL spread, over/under and money line projections provided by SportsLine AI.
Built by SportsLine’s data science team using cutting-edge artificial intelligence and machine learning technology, AI predictions and AI ratings are generated for each game. AI predictions are determined by statistically learning from historical data for each team and quantitatively rating the strength of the opponent’s defense by assigning it a numerical value out of 100, called a Matchup Score.
Once a prediction is formulated, an AI rating is generated using the prediction, match score and market odds. For example, if a team has a weak defense, the prediction differs from the line and the odds are in your favour, you may see an A rating on an over bet.
Plus, SportsLine AI is SportsLine’s first fully automated prediction model, which is continually updated with the latest available data to help you find the biggest discrepancies in lines. Last season, SportsLine’s AI PickBot hit 1,674 4.5- and 5-star prop picks, a difference that anyone who’s used the tool can attest to.
In Week 1, AI PickBot evaluated the NFL odds and provided NFL predictions for all 16 games. Here you can see only the AI predictions for Week 1 NFL schedule.
Top NFL AI picks for Week 1
AI PickBot has the Broncos covering a 6-point deficit against the Seahawks in a game that earned them an A-rated pick after analyzing all of the Week 1 games. After ranking last in the NFL in points per game in 2022, Sean Payton made a clear difference in 2023, with Denver finishing 19th in points in his first season. Meanwhile, the defense dropped from 7th to 29th in yards allowed, but was able to hold on by forcing turnovers and standing strong on third downs.
The Broncos were 12th in the NFL with 26 turnovers and second in the league in opponent third-down conversion rate (33.2%). Meanwhile, Seattle’s defense struggled to get off the field on third downs last season, allowing opponents to convert on 46.2% of their opportunities (30th in the NFL). That’s a big reason why our AI PickBot sees this game as much closer than oddsmakers do, projecting the Seahawks with an average chance of winning of 21.86 to 20.34. See more Week 1 football predictions and football picks at SportsLine.
How to make your Week 1 NFL picks
Additionally, AI PickBot generated eight A-rated picks for Week 1. Before you place any NFL bets for Week 1, you should check out AI PickBot’s analysis, which you can find exclusively at SportsLine.
Who will win and cover each NFL game in Week 1, and which A-rated picks should you bet on? Visit SportsLine now for the top NFL picks against the spread, over-under and money line, all powered by the all-new SportsLine AI PickBot, which hit the mark on 1,674 top-rated picks last season.
