Sunday’s Steelers vs. Chargers will be the first game since 1986 featuring the top two scoring defenses at 2-0. While both are elite defensively, LA ranks 11th in scoring offenses and Pittsburgh ranks just 25th. Despite that, the Week 3 NFL line has the Steelers favored by 2.5 points with a total score of 35. Both teams are 2-0 ATS and the under is 2-0 ATS for both teams. However, this matchup features one of the tightest NFL spreads in Week 3, so unless you’re confident on one side of the spread, picking NFL football with the over/under alone would be the right NFL betting advice. Before making your Week 3 NFL picks, you should check out the NFL spread, over/under and moneyline projections provided by SportsLine AI.
Built by SportsLine’s data science team using cutting-edge artificial intelligence and machine learning technology, AI predictions and AI ratings are generated for each game. AI predictions are determined by statistically learning from historical data for each team and quantitatively rating the strength of the opponent’s defense by assigning it a numerical value out of 100, called a Matchup Score.
Once a prediction is formulated, an AI rating is generated using the prediction, match score and market odds. For example, if a team has a weak defense, the prediction differs from the line and the odds are in your favour, you may see an A rating on an over bet.
Plus, SportsLine AI is SportsLine’s first fully automated prediction model, which is continually updated with the latest available data to help you find the biggest discrepancies in lines. Last season, SportsLine’s AI PickBot hit 1,674 4.5- and 5-star prop picks, a difference that anyone who’s used the tool can attest to.
For Week 3 NFL betting, AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. Here you can see only the AI predictions for Week 3 NFL schedule.
Top NFL AI picks for Week 3
AI PickBot predicts the Rams to cover as 6.5-point underdogs at home against the 49ers after analyzing all the games in Week 3. The team is 5-2 against the spread as home underdogs since Matthew Stafford joined the Rams in 2021. The Rams are 4-0 straight up in their last four home games and have covered in their last three, so they will also be feeling confident heading back to Los Angeles after opening with back-to-back away games.
Both teams are coming into this game with injuries, with Puka Nacua, Cooper Kupp, Christian McCaffrey and Deebo Samuel all out. But their absence will be felt on the ground and in the air, given the rushing and receiving abilities of the injured Niners duo. LA still has reliable running back Kyren Williams, who recorded 100 scrimmage yards and two touchdowns last year against San Francisco. He’s scored in two games this season and has a total of 17 touchdowns in his past 14 regular season games. His presence will help LA compensate for the injuries to its receivers. The AI model projects the 49ers (-3.5) to win by two points or less. See more Week 3 football predictions and football picks at SportsLine.
How to make your Week 3 NFL picks
Additionally, AI PickBot has generated five A-rated picks for Week 3. Before you place your own bets on the NFL in Week 3, you should take a look at AI PickBot’s picks, which you can find exclusively at SportsLine.
Who will win and cover each NFL game in Week 3, and which A-rated picks should you target? Visit SportsLine now for the top NFL picks against the spread, over-under and money line, all powered by the all-new SportsLine AI PickBot, which hit the mark on 1,674 top-rated picks last season.